Oliver Nayler, PhD, Founder
Oliver Nayler has a knack for solving biological puzzles—and a career to prove it. With a biochemistry degree from ETH Zürich (plus a shiny silver medal to go with it) and PhD work performed at the Laboratory of Molecular Biology in Cambridge, he dived into the molecular world with curiosity and precision. His postdoc years at the Max Planck Institute for Biochemistry laid the groundwork for two decades of leading discovery efforts at Actelion and Idorsia, contributing to the approval of several first-in-class drugs. In 2024, he took the helm as Head of Drug Discovery at leadXpro, pushing the frontiers of structure-based membrane protein targeted drug discovery. Oliver blends scientific rigor with a collaborative spirit. When he is not decoding cell signaling, he is probably inspiring the next generation of drug hunters.
Key Publications
Brisbare-Roch et al. Promotion of sleep by targeting the orexin system in rats, dogs and humans. Nat Med 13, 150–155 (2007) Link to nature
Nayler et al. Serotonin biosynthesis as a predictive marker of serotonin pharmacodynamics and disease-induced dysregulation. Sci Rep 6, 30059 (2016) Link to Nature Scientific Reports
Nayler et al. MMP-7 is a predictive biomarker of disease progression in patients with idiopathic pulmonary fibrosis. ERJ Open Res. 0074-2016 (2017) Link to ERS